Hydrochloric Acid → 2-(5-Formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Beteiligte Stoffe

Reaktionsschritte

A mixture of 0.9023 g (1.87 mmole) of 2-(5-dimethoxymethyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide, 34 mL of acetonitrile and 17 mL of 1M hydrochloric acid was heated at 60 degrees for 2 hours. The cooled mixture was diluted with 50 mL of water. The resulting precipitate was collected by filtration, washed with water and dried to give 0.5766 g of 2-(5-formyl-2-nitro-phenylamino)-4-(4-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide (VI.47b) as an orange-red solid.

Herkunft & Nachweise