Cesium carbonate → 2-(5-Dimethoxymethyl-2-nitro-phenylamino)-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

참여 물질

반응 단계

A mixture of 0.5691 g (1.981 mmole) of 2-amino-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide (V.48), 0.4515 g (2.098 mmole) of 4-dimethoxymethyl-2-fluoro-1-nitro-benzene 29 mL of dimethylformamide and 3.2215 g (9.877 mmole) of cesium carbonate was heated at 56 degrees for 4 hours. The cooled mixture was poured into dilute aqueous ammonium chloride solution. The precipitate was collected by filtration, washed with water, and dried to give 0.8344 g of 2-(5-dimethoxymethyl-2-nitro-phenylamino)-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide (VI.48a) as a brown-orange solid.

출처 및 근거