Hydrochloric Acid → 2-(5-Formyl-2-nitro-phenylamino)-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

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Reaction Steps

A mixture of 0.4154 g (0.861 mmole) of 2-(5-dimethoxymethyl-2-nitro-phenylamino)-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide, 16 mL of acetonitrile and 8 mL of 1M hydrochloric acid was heated at 60 degrees for 1.5 hours. The cooled mixture diluted with 50 mL of water. The precipitate was collected by filtration, washed with water and dried to give 0.3198 g of 2-(5-formyl-2-nitro-phenylamino)-4-(3-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide (VI.48b) as an orange solid.

Provenance & Evidence