HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1,4-dimethyl-1H-pyrazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 1,4-dimethyl-1H-pyrazole-5-carboxylate | HCID 21784699 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,4-dimethyl-1H-pyrazole-5-carboxylic acid | HCID 643150 | 55.4% |
Reaction Steps
Using ethyl 1,4-dimethyl-1H-pyrazole-5-carboxylate (565 mg, 3.36 mmol), 1N aqueous sodium hydroxide solution (4 mL, 4 mmol) and ethanol (4 mL), and by a reaction in the same manner as in Reference Example 20, the title compound (261 mg, 55%) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044049B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-d4bc0f84cb6248ad84241bd272daf678 |
| Source note | uspto-grants-2011_10 |