Sodium Hydroxide → 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylic acid

HRID 1667862Notes

Reaction equation

HRID 1667862 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]([O:13]C)=[O:12])[N:8]([CH3:15])[N:7]=1.[OH-].[Na+]>CO>[CH3:1][O:2][CH2:3][CH2:4][O:5][C:6]1[CH:10]=[C:9]([C:11]([OH:13])=[O:12])[N:8]([CH3:15])[N:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57441051methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate

Product 1

HCID 574410523-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylic acidYield 96.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using methyl 3-(2-methoxyethoxy)-1-methyl-1H-pyrazole-5-carboxylate (3.03 g, 14.1 mmol), methanol (15 mL) and 8N aqueous sodium hydroxide solution (3.00 mL), and in the same manner as in Reference Example 58, the title compound (2.72 g, yield 96%) was obtained.

Sources & evidence

ORD record
ord-f8de302a41ad48ff865b6ff92c98a1eb
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Reaction notes

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