Methanol → 4-[2,2-Bis-(4-chloro-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:18](=[O:19])([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[N:25]1[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]1.[C:31]([BH3-:32])#[N:33].[CH3:36][OH:37].[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH:9]=[O:10])[c:11]2[cH:12][cH:13][c:14]([Cl:17])[cH:15][cH:16]2)[cH:6][cH:7]1.[Na+:34].[OH2:35]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH2:9][N:28]2[CH2:27][CH2:26][N:25]([C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH2:30][CH2:29]2)[c:11]2[cH:12][cH:13][c:14]([Cl:17])[cH:15][cH:16]2)[cH:6][cH:7]1Participants
7
Sources & evidence
- ORD record
- ord-6dab23b1f84644a8b3d06ee881b28c47
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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