Dimethylformamide → HCID 57505521, compound

Participants

Reaction Steps

Using 1,3-dimethyl-1H-pyrazole-5-carboxylic acid (113 mg, 0.81 mol), tetrahydrofuran (4.0 mL), N,N-dimethylformamide (30 μL, 0.39 mmol), oxalyl chloride (141 μL, 1.61 mmol), N-[6-(3-aminophenoxy)imidazo[1,2-b]pyridazin-2-yl]propionyl carboxamide (200 mg, 0.67 mmol) and N,N-dimethylacetamide (4.0 mL) as starting materials and in the same manner as in Example 119, the title compound (190 mg, 67%) was obtained as a white powder.

Provenance & Evidence