3-Pyridinemethanamine → 2-Chloro-5-fluoro-N-(3-pyridinylmethyl)-4-pyrimidinamine

HRID 166801Notes

Reaction equation

HRID 166801 reaction equation
[CH2:1]1[CH2:2][O:3][c:4]2[cH:5][cH:6][c:7]([NH:8][c:9]3[c:10]([F:11])[cH:12][n:13][c:14]([NH:15][c:16]4[cH:17][cH:18][cH:19][c:20]([OH:21])[cH:22]4)[n:23]3)[cH:24][c:25]2[O:26]1.[Cl:35][c:36]1[n:37][cH:38][c:39]([F:43])[c:40]([Cl:42])[n:41]1.[n:27]1[cH:28][c:29]([CH2:33][NH2:34])[cH:30][cH:31][cH:32]1>>[n:27]1[cH:28][c:29]([CH2:33][NH:34][c:40]2[c:39]([F:43])[cH:38][n:37][c:36]([Cl:35])[n:41]2)[cH:30][cH:31][cH:32]1

Participants

4

Reactant 3

HCID 310183-PyridinemethanamineHCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 22060334N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-primidinediamine

Product 1

HCID 220609912-Chloro-5-fluoro-N-(3-pyridinylmethyl)-4-pyrimidinamine

Sources & evidence

ORD record
ord-e9e3f6cda2a244f68b0ef2fe70741af3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…