HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-[6-(3-amino-4-methoxyphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Amino-4-methoxyphenol | HCID 20341841 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)acetamide | HCID 57441059 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[6-(3-amino-4-methoxyphenoxy)imidazo[1,2-b]pyridazin-2-yl]cyclopropanecarboxamide | HCID 57505589 | 125.6% |
Reaction Steps
Using 3-amino-4-methoxyphenol (408 mg, 2.93 mmol), N,N-dimethylformamide (16 mL), potassium tert-butoxide (343 mg, 3.05 mmol), N-(6-iodoimidazo[1,2-b]pyridazin-2-yl)acetamide (800 mg, 2.44 mmol) and potassium carbonate (169 mg, 1.22 mmol), and in the same manner as in Example 216, the title compound (1.04 g, 42%) was obtained as a brown powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08044049B2 |
| Source dataset | uspto-grants-2011_10 |
| ORD ID | ord-05164ed4c7524dccac1728ee34c7d89f |
| Source note | uspto-grants-2011_10 |