Sodium Hydroxide → HCID 57505639, compound

HRID 1668091Notes

Reaction equation

[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([S:15][C:16]4[CH:25]=[CH:24][CH:23]=[CH:22][C:17]=4[C:18]([O:20]C)=[O:19])=[N:11][N:10]3[CH:26]=2)=[O:5])[CH2:3][CH2:2]1.[OH-].[Na+]>>[CH:1]1([C:4]([NH:6][C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([S:15][C:16]4[CH:25]=[CH:24][CH:23]=[CH:22][C:17]=4[C:18]([OH:20])=[O:19])=[N:11][N:10]3[CH:26]=2)=[O:5])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 57505640HCID 57505640, compound

Product 1

HCID 57505639HCID 57505639, compoundYield 92%

Procedure

In the same manner as in Example 276 and using methyl 2-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}thio)benzoate (390 mg, 1.1 mmol) and 4N aqueous sodium hydroxide solution (2 mL) as starting materials, the title compound (340 mg, 92%) was obtained as a pale-yellow solid.

Sources & evidence

ORD record: ord-3f20fb7ffe2b4056857f446fb58db3d8
Source dataset: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08044049B2

Reaction notes

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