Acetyl chloride → HCID 57386062, compound

HRID 1668203Notes

Reaction equation

HRID 1668203 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([O:10][C:11]3[CH:12]=[C:13]([NH:17][C:18](=[O:29])[C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=4)[CH:14]=[CH:15][CH:16]=3)=[N:6][N:5]2[CH:30]=1.[C:31](Cl)(=[O:33])[CH3:32]>N1C=CC=CC=1>[C:31]([NH:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([O:10][C:11]3[CH:12]=[C:13]([NH:17][C:18](=[O:29])[C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([C:25]([F:28])([F:27])[F:26])[CH:20]=4)[CH:14]=[CH:15][CH:16]=3)=[N:6][N:5]2[CH:30]=1)(=[O:33])[CH3:32]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 57385788N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide

Product 1

HCID 57386062HCID 57386062, compoundYield 60.1%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Using N-{3-[(2-aminoimidazo[1,2-b]pyridazin-6-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide (150 mg, 0.362 mmol), acetyl chloride (31 μL, 0.435 mmol) and pyridine (3 mL) as starting materials and in the same manner as in Example 384, the title compound (99 mg, 60%) was obtained as a pale-yellow powder.

Sources & evidence

ORD record
ord-e5c6e0ea8ac049d6a53eb816183924b5
Source dataset
uspto-grants-2011_10
Patent number
US08044049B2

Reaction notes

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