HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → Methyl 4-(1H-imidazol-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 4-fluorobenzoate | HCID 67878 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 4-(1H-imidazol-1-yl)benzoate | HCID 2766374 | 59% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A mixture of imidazole (132 g, 1.9 mol), methyl 4-fluorobenzoate (170 ml, 1.3 mol) and potassium carbonate (357 g, 2.6 mol) in DMSO (200 ml) is stirred at 120° C. for 3 h. After cooling to room temperature, the mixture is added to ice-water. Precipitated product is filtered off and washed with water. Yield: 59%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989091B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-0cef180ce2cc4b3cbe4fcec96a5d2fd5 |
| Source note | uspto-grants-2011_08 |