Acetyl chloride → HCID 67358615, compound

Participants

Reaction Steps

To a solution of 0.4 g (1.05 mmol) (−)-(cis)-7-bromo-8,14-difluoro-1,3,4,14b-tetrahydro-2H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepine-1-amine in a mixture of CH2Cl2 (10 mL) and triethylamine (0.44 mL, 3.15 mmol), acetyl chloride (0.187 mL, 2.62 mmol) in CH2Cl2 (5 mL) was added and it was stirred at ambient temperature for 1 h. Saturated (aq) NaHCO3 was added and the organic layers were washed with brine, dried (Na2SO4) and concentrated under reduced pressure to afford the crude compound which was used without further purification (0.44 g, 100%).

Provenance & Evidence