Carbon tetrabromide → HCID 19790700, compound

Participants

Reaction Steps

A solution of benzyl {2-[4-(hydroxymethyl)phenyl]ethyl}carbamate (1 g), triphenylphosphine (0.97 g) and carbon tetrabromide (1.2 g) in acetonitrile (1 ml) was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by column chromatography [developing solvent:ethyl acetate-hexane (1:5, volume ratio)] and crystallized from hexane to give the title compound (0.96 g) as a colorless powder.

Provenance & Evidence