Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate | HCID 11544322 | — |
| Reactant | HCID 67360624 | HCID 67360624 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59239823 | HCID 59239823 | 62.8% |
Reaction Steps
A mixture of methyl 5-(4-chlorophenyl)-3-(dimethylaminomethyleneamino)thiophene-2-carboxylate (0.2 g), 2-[4-(1-piperidin-1-ylethyl)phenyl]ethanamine dihydrochloride (0.19 g), N,N-diisopropylethylamine (0.20 g) and ethanol (4 ml) were stirred at 70° C. for 3 hr. The reaction mixture was allowed to cool, ethyl acetate was added, and the precipitate was collected by filtration to give the title compound (186 mg) as a colorless powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07989445B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-28fb6fb262c34c3a922001123bd4fed5 |
|---|
| Source note | uspto-grants-2011_08 |
|---|
