Hydrogen chloride-ethyl acetate → 6-(4-chlorophenyl)-3-(2-{4-[(methylamino)methyl]phenyl}ethyl)thieno[3,2-d]pyrimidin-4(3H)-one dihydrochloride

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Reaction Steps

A mixture of the compound (0.18 g) obtained in Example 3 and 4N hydrogen chloride-ethyl acetate solution was stirred at room temperature for 1 hr. The solvent was evaporated under reduced pressure, and the residue was washed with ethyl acetate to give the title compound (0.17 g) as a colorless powder.

Provenance & Evidence