Sodium borohydride → HCID 67359952, compound

Participants

Reaction Steps

tert-Butyl 2-acetyl-1-[4-(cyanomethyl)phenyl]-2-methylhydrazinecarboxylate (607 mg) and cobalt chloride (520 mg) were dissolved in methanol (20 ml), and sodium borohydride (757 mg) was added by small portions at 0° C. The reaction mixture was stirred at room temperature for 2.5 hr, and diluted with ethyl acetate (200 ml). The obtained diluted solution was passed through basic silica gel (100 g) and washed with ethyl acetate:methanol=10:1 (volume ratio). The filtrate was concentrated under reduced pressure to give tert-butyl 2-acetyl-1-[4-(2-aminoethyl)phenyl]-2-methylhydrazinecarboxylate as a colorless oil.

Provenance & Evidence