Trifluoroacetic acid → HCID 59239846, compound

Participants

Reaction Steps

tert-Butyl 2-acetyl-1-[4-[2-[6-(4-chlorophenyl) -4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]ethyl]phenyl]-2-methylhydrazinecarboxylate (356 mg) was dissolved in dichloromethane (6.5 ml), and trifluoroacetic acid (2.0 ml) was added. The reaction mixture was stirred at room temperature for 1.5 hr, and diluted with dichloromethane. The obtained diluted solution was washed with saturated aqueous sodium hydrogen carbonate solution, the organic layer was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The precipitated crystals were washed with ethyl acetate-diisopropyl ether to give the title compound (287 mg) as colorless crystals.

Provenance & Evidence