Methyl iodide → HCID 11999426, compound

Participants

Reaction Steps

N′-[4-[2-[6-(4-Chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]ethyl]phenyl]-N-methylacetohydrazide (106 mg) was suspended in DMF (7.0 ml), and methyl iodide (17 μl) and then sodium hydride (60%, 10 mg) were added at 0° C. The obtained mixture was stirred at room temperature for 4.5 hr, and methyl iodide (17 μl) and then sodium hydride (60%, 10 mg) were added at 0° C. The obtained mixture was stirred at room temperature for 24 hr, diluted with chloroform, and washed with water and then saturated brine. The organic layer was dried over sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform→chloroform:methanol=50:1 (volume ratio)) and further washed with ethyl acetate to give the title compound (50.1 mg) as colorless crystals.

Provenance & Evidence