HCID 11379627, compound → HCID 11160262, compound

Participants

Reaction Steps

A solution of compound 23 (0.35 g, 1.415 mmol) in dry ethanol (3 mL) was treated with Pd—C (˜0.05 g) and flushed with hydrogen gas. The reaction was stirred under hydrogen atm. for overnight. The reaction was filtered through celite bed, washed with methanol (3×10 mL) and dried to obtain crude compound 24 (0.29 g, 94%) as a syrup. 1H NMR (DMSO-d6) δ 2.18 (s, 6H), 2.32 (s, 3H), 2.42 (t, 2H, J=7.2 Hz), 4.03 (t, 2H, J=7.2 Hz), 4.37 (s, 2H), 5.88 (s, 1H), 6.42 (dd, 1H, J=2.1, 8.4 Hz), 6.56 (d, 1H, J=2.1 Hz), 7.00 (d, 1H, J=8.7 Hz); ESI-MS (m/z, %) 218 (MH+, 100).

Provenance & Evidence