HCID 57421471, compound → HCID 57421478, compound

Participants

Reaction Steps

A solution of compound 26 (0.44 g, 1.609 mmol) in dry ethanol (5 mL) was treated with Pd—C (˜0.05 g) and flushed with hydrogen gas. The reaction was stirred under hydrogen atm. for overnight. The reaction was filtered through celite bed, washed with methanol (3×10 mL) and dried to obtain crude compound 27 (0.39 g, quantitative) as a syrup. 1H NMR (DMSO-d6) δ 1.60-1.70 (m, 4H), 2.32 (s, 3H), 2.40-2.48 (m, 4H), 2.60 (t, 2H, J=7.2 Hz), 4.06 (t, 2H, J=7.2 Hz), 4.37 (s, 2H), 5.88 (s, 1H), 6.42 (dd, 1H, J=2.1, 8.7 Hz), 6.56 (d, 1H, J=1.8 Hz), 7.00 (d, 1H, J=8.4 Hz); ESI-MS (m/z, %) 244 (MH+, 100).

Provenance & Evidence