HCID 59004670, compound → HCID 59004615, compound

Participants

Reaction Steps

A solution of compound 29 (0.5 g, 1.739 mmol) in dry ethanol (3 mL) was treated with Pd—C (˜0.05 g) and flushed with hydrogen gas. The reaction was stirred under hydrogen atm. for overnight. The reaction was filtered through celite bed, washed with methanol (3×15 mL) and dried to obtain crude compound 31 (0.34 g, 77%) as a syrup. 1H NMR (DMSO-d6) δ 1.40-1.67 (m, 4H), 1.82-1.93 (m, 2H), 1.98-2.10 (m, 2H), 2.18 (s, 3H), 2.31 (s, 3H), 2.90-2.96 (m, 1H), 3.97 (t, 2H, J=7.5 Hz), 4.39 (s, 2H), 5.88 (s, 1H), 6.43 (dd, 1H, J=2.1, 8.4 Hz), 6.57 (d, 1H, J=1.8 Hz), 7.00 (d, 1H, J=8.7 Hz); ESI-MS (m/z, %) 258 (MH+, 28), 161 (100).

Provenance & Evidence