HCID 59004598, compound → HCID 59004626, compound

Participants

Reaction Steps

A solution of compound 75 (200 mg, 0.79 mmol) in methanol (10 mL) was added to Raney Nickel (slurry in H2O, 50 mg) in a round bottom flask. The suspension was heated at reflux for 10 minutes then filtered through a pad of celite. The celite pad washed with methanol (20 mL). The filtrate was concentrated and the residue was subjected to silica gel chromatography (CH2Cl2 to MeOH:CH2Cl2, 1:9) to give compound 76 (140 mg, 79.1%) as an off-white solid. 1H NMR (DMSO-d6) δ 8.01 (d, J=2.7 Hz, 1H), 7.51 (dd, J=2.9, 6.1 Hz, 1H), 7.27 (d, J=3.0 Hz, 1H), 7.04 (d, J=8.6 Hz, 1H), 6.73 (d, J=2.1 Hz, 1H), 6.59 (s, 1H), 6.56 (s, 1H), 6.55 (dd, J=2.1, 6.8 Hz, 1H), 6.33 (d, J=3.0 Hz, 1H), 6.10 (brs, 2H), 4.61 (brs, 2H); ESI-MS (m/z, %): 225 (M+1, 100%).

Provenance & Evidence