1-(Tetrahydro-2H-pyran-4-yl)-1H-indol-5-amine → HCID 178511912, compound

HRID 1668482Notes

Reaction equation

HRID 1668482 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][C:12]([NH2:16])=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:3][CH2:2]1.I.CS[C:20]([C:22]1[S:23][CH:24]=[CH:25][CH:26]=1)=[NH:21]>C(O)C>[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:15]3[C:10](=[CH:11][C:12]([NH:16][C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)=[NH:21])=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 590046181-(Tetrahydro-2H-pyran-4-yl)-1H-indol-5-amineHCID 66704664Methyl thiophene-2-carbimidothioate hydroiodide

Product 1

HCID 178511912HCID 178511912, compoundYield 31.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 89 (95 mg, 0.439 mmol) is charged to a small, argon purged flask fitted with a magnetic stir bar. Anhydrous ethanol (5 mL) and thiophene-2-carboximidothioic acid methyl ester hydroiodide (219.2 mg, 0.769 mmol) are added to the flask and the reaction was stirred under argon at ambient temperature for 21 hours, at which time the solvent was evaporated and the residue was partitioned between H2O and ethyl acetate and 1M sodium hydroxide solution added to adjust pH to 9. The mixture was transferred to a separatory funnel and the organic layer collected. The aqueous layer was further extracted with ethyl acetate and the combined organic layers were washed with brine, dried over magnesium sulphate, filtered, concentrated and the residue purified via chromatography on silica gel (methanol:CH2Cl2, 5:95 to 7.5:92.5) to yield a pale yellow residue, 90 (45 mg, 31.5%). 1H NMR (DMSO-d6) δ 1.82-2.11 (m, 4H), 3.57 (t, 2H, J=11.0 Hz), 3.92-4.07 (m, 2H), 4.50-4.68 (m, 1H), 6.33 (brs, 2H), 6.37 (d, 1H, J=2.5 Hz), 6.71 (d, 1H, J=8.2 Hz), 7.00 (s, 1H), 7.09-7.11 (m, 1H), 7.45 (d, 1H, J=2.7 Hz), 7.52 (d, 1H, J=8.6 Hz), 7.60 (d, 1H, J=4.8 Hz), 7.72 (d, 1H, J=2.7 Hz); ESI-MS (m/z, %): 326 (MH+, 100%); ESI-HRMS calculated for C18H20N3OS (MH+): 326.1321, observed: 326.1332.

Workup

  1. customfitted with a magnetic stir bar
  2. customwas evaporated
  3. customthe residue was partitioned between H2O and ethyl acetate and 1M sodium hydroxide solution
  4. additionadded
  5. customThe mixture was transferred to a separatory funnel
  6. customthe organic layer collected
  7. extractionThe aqueous layer was further extracted with ethyl acetate
  8. washthe combined organic layers were washed with brine
  9. dry with materialdried over magnesium sulphate
  10. filtrationfiltered
  11. concentrationconcentrated
  12. customthe residue purified via chromatography on silica gel (methanol:CH2Cl2, 5:95 to 7.5:92.5)

Sources & evidence

ORD record
ord-d1ccdd6542894678bdcfad2f3a26d9c6
Source dataset
uspto-grants-2011_08
Patent number
US07989447B2

Reaction notes

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