Ammonia → HCID 66853748, compound

Participants

Reaction Steps

To 0.3 g of the compound of Example 30 was added 2 mL of trifluoroacetic acid, and the mixture was stirred at room temperature for 1 hour. Then the trifluoroacetic acid was removed under reduced pressure from the reaction mixture, the residue was dissolved in 2 mL of acetonitrile. To resulting solution was added 4 mL of 28% aqueous ammonia, and the resulting crystal was filtrated to give 0.2 g of N-{4-[6-amino-2-(6-aminomethylpyridin-2-ylmethylsulfanyl)-5-cyano-pyrimidin-4-yl]phenyl}acetamide as a white powder.

Provenance & Evidence