反应详情

1,1-dimethylethyl 7-nitro-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (3.25 g) was hydrogenated for 3 h under atmospheric pressure at 25° C. in the presence of 10% Pd/C (0.32 g) in MeOH (130 ml). The catalyst was removed by filtration, the solvent evaporated under reduced pressure and the resulting residue was purified by flash chromatography over silica gel (eluting with 40% ethyl acetate in hexane) to give the title compound (2.55 g).

1. customThe catalyst was removed by filtration
2. customthe solvent evaporated under reduced pressure
3. customthe resulting residue was purified by flash chromatography over silica gel (eluting with 40% ethyl acetate in hexane)