Sodium Hydroxide → HCID 59150481, compound

Participants

Reaction Conditions

Reaction Steps

1,1-dimethylethyl 7-(ethanethioylamino)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (411 mg), was dissolved in MeOH (12 ml), and 1N NaOH (6.1 ml) and added to potassium ferricyanide [K3Fe(CN)6] (2.1 g), in H2O (12 ml). This mixture was warmed up to 60° C. for 1.5 h, cooled at rt. concentrated and the material thus obtained was purified by flash chromatography over silica gel, eluting with 20% ethyl acetate in hexane, affording a 2:1 mixture of title compound and its regioisomer (167 mg) that was further used as such.

Provenance & Evidence