HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-dimethylethyl 10-bromo-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine-7-carboxylate → HCID 59150520, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-dimethylethyl 10-bromo-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine-7-carboxylate | HCID 59150483 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59150520 | HCID 59150520 | 99.3% |
Reaction Steps
To a stirred solution of 1,1-dimethylethyl 10-bromo-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine-7-carboxylate (71 mg) in DCM (2.1 ml) TFA (0.9 ml) was added dropwise. After 30 min. the mixture was diluted with DCM and washed with 5% K2CO3. The organic phase was dried (Na2SO4) and concentrated to afford the title compound (52 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989444B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-e5cb115952d54dee87f8de6278c8ea9d |
| Source note | uspto-grants-2011_08 |