HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoacetate → HCID 59150518, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoacetate | HCID 15050 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | HCID 67358883 | HCID 67358883 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 59150518 | HCID 59150518 | 94% |
Reaction Steps
1,1-Dimethylethyl 8-amino-7-hydroxy-6-methyl-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (1.1 g) was treated with trimethyl orthoacetate (0.718 ml) and pyridinium p-toluenesulfonate (94 mg) in dry DMF (19 ml) at 60° C. for 1.5 hours. Volatiles were evaporated under reduced pressure and the residue was purified on silica gel (ethyl acetate/petroleum ether: 1/4) providing the title compound as white solid (1.127 g, 94% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989444B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-06d78a82c2f2444b9742829b442d28dc |
| Source note | uspto-grants-2011_08 |