1,1,1-Trimethoxypropane → HCID 59150493, compound

Participants

Reaction Steps

1,1-Dimethylethyl 8-amino-7-hydroxy-6-methyl-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (1.1 g) was treated with trimethyl orthopropionate (0.802 ml) and pyridinium p-toluenesulfonate (0.1 eq) in dry DMF (19 ml) at 60° C. for 1.5 hours. Volatiles were evaporated under reduced pressure and the residue was purified on silica gel (ethyl acetate/petroleum ether: 1/4) providing the title compound as white solid (1.18 g, 95% yield).

Provenance & Evidence