Trifluoroacetic acid → HCID 86638056, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl 1-hydroxy-2-(1-methylethyl)-3-oxo-2,3,5,6,8,9-hexahydroazepino[4,5-f]isoindole-7(1H)-carboxylate (1.0 g) and triethylsilane (0.95 ml) in DCM (20 ml), at 0° C., TFA (10 ml) was added dropwise and the mixture stirred for 1 h. the mixture was neutralized with 2M aqueous Na2CO3 and washed with ether discarding the organic layer. Then the aqueous layer was made basic with NaOH and extracted with DCM. The organic solution was washed with brine, dried over Na2SO4 and concentrated to afford a pale yellow solid (0.6 g, 88% yield).

Provenance & Evidence