3-[(3-Chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole → 2-(1-Methylethyl)-7-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668605Notes

Reaction equation

HRID 1668605 reaction equation
[CH3:1][CH:2]([C:4]1[O:5][C:6]2[C:16]([N:17]=1)=[CH:15][C:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14][C:8]=1[CH:7]=2)[CH3:3].[Cl:18][CH2:19][CH2:20][CH2:21][S:22][C:23]1[N:27]([CH3:28])[C:26]([C:29]2[O:33][CH:32]=[N:31][C:30]=2[CH3:34])=[N:25][N:24]=1>>[ClH:18].[CH3:3][CH:2]([C:4]1[O:5][C:6]2[C:16]([N:17]=1)=[CH:15][C:9]1[CH2:10][CH2:11][N:12]([CH2:19][CH2:20][CH2:21][S:22][C:23]3[N:27]([CH3:28])[C:26]([C:29]4[O:33][CH:32]=[N:31][C:30]=4[CH3:34])=[N:25][N:24]=3)[CH2:13][CH2:14][C:8]=1[CH:7]=2)[CH3:1]

Participants

3

Reactant 2

HCID 446279943-[(3-Chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazoleHCID 591504992-(1-Methylethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine

Product 1

HCID 673587512-(1-Methylethyl)-7-(3-{[4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-(1-methylethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.21 mmol) and 3-[(3-chloropropyl)thio]-4-methyl-5-(4-methyl-1,3-oxazol-5-yl)-4H-1,2,4-triazole and was obtained as a colourless slightly hygroscopic solid (78 μmol).

Sources & evidence

ORD record
ord-9346b3829b38426b8f0bc8f92e392053
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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