5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → HCID 67358944, compound

HRID 1668608Notes

Reaction equation

HRID 1668608 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[O:4][C:5]2[C:15]([N:16]=1)=[CH:14][C:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][C:7]=1[CH:6]=2.[Cl:19][CH2:20][CH2:21][CH2:22][S:23][C:24]1[N:25]([CH3:40])[C:26]([C:29]2[CH:38]=[CH:37][CH:36]=[C:35]3[C:30]=2[CH:31]=[CH:32][C:33]([CH3:39])=[N:34]3)=[N:27][N:28]=1>>[ClH:19].[CH3:40][N:25]1[C:26]([C:29]2[CH:38]=[CH:37][CH:36]=[C:35]3[C:30]=2[CH:31]=[CH:32][C:33]([CH3:39])=[N:34]3)=[N:27][N:28]=[C:24]1[S:23][CH2:22][CH2:21][CH2:20][N:11]1[CH2:10][CH2:9][C:8]2[CH:14]=[C:15]3[N:16]=[C:3]([C:2]([F:17])([F:1])[F:18])[O:4][C:5]3=[CH:6][C:7]=2[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 251050505-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 59150536HCID 59150536, compound

Product 1

HCID 67358944HCID 67358944, compound

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-(trifluoromethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.14 μmol) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline and was obtained as a colourless solid (97 μmol).

Sources & evidence

ORD record
ord-b978df567c174e6aadb6142c72faa4c0
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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