5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 4-Methyl-8-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-4,6,7,8,9,10-hexahydro[1,4]oxazino[2,3-h][3]benzazepin-3(2H)-one hydrochloride

HRID 1668609Notes

Reaction equation

HRID 1668609 reaction equation
[CH3:1][N:2]1[C:7]2=[CH:8][C:9]3[CH2:15][CH2:14][NH:13][CH2:12][CH2:11][C:10]=3[CH:16]=[C:6]2[O:5][CH2:4][C:3]1=[O:17].[Cl:18][CH2:19][CH2:20][CH2:21][S:22][C:23]1[N:24]([CH3:39])[C:25]([C:28]2[CH:37]=[CH:36][CH:35]=[C:34]3[C:29]=2[CH:30]=[CH:31][C:32]([CH3:38])=[N:33]3)=[N:26][N:27]=1>>[ClH:18].[CH3:1][N:2]1[C:7]2=[CH:8][C:9]3[CH2:15][CH2:14][N:13]([CH2:19][CH2:20][CH2:21][S:22][C:23]4[N:24]([CH3:39])[C:25]([C:28]5[CH:37]=[CH:36][CH:35]=[C:34]6[C:29]=5[CH:30]=[CH:31][C:32]([CH3:38])=[N:33]6)=[N:26][N:27]=4)[CH2:12][CH2:11][C:10]=3[CH:16]=[C:6]2[O:5][CH2:4][C:3]1=[O:17]

Participants

3

Reactant 2

HCID 251050505-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 584946054-Methyl-4,6,7,8,9,10-hexahydro[1,4]oxazino[2,3-h][3]benzazepin-3(2H)-one

Product 1

HCID 673593494-Methyl-8-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-4,6,7,8,9,10-hexahydro[1,4]oxazino[2,3-h][3]benzazepin-3(2H)-one hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 4-methyl-4,6,7,8,9,10-hexahydro[1,4]oxazino[2,3-h][3]benzazepin-3(2H)-one (37 mg) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline and was obtained as a colourless sticky solid (41 mg).

Sources & evidence

ORD record
ord-534ea1f42659473ca342c3e67d3f7ddf
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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