5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 3-Methyl-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668614Notes

Reaction equation

HRID 1668614 reaction equation
[CH3:1][C:2]1[C:15]2[C:5](=[CH:6][C:7]3[CH2:13][CH2:12][NH:11][CH2:10][CH2:9][C:8]=3[CH:14]=2)[O:4][N:3]=1.[Cl:16][CH2:17][CH2:18][CH2:19][S:20][C:21]1[N:22]([CH3:37])[C:23]([C:26]2[CH:35]=[CH:34][CH:33]=[C:32]3[C:27]=2[CH:28]=[CH:29][C:30]([CH3:36])=[N:31]3)=[N:24][N:25]=1>>[ClH:16].[CH3:1][C:2]1[C:15]2[C:5](=[CH:6][C:7]3[CH2:13][CH2:12][N:11]([CH2:17][CH2:18][CH2:19][S:20][C:21]4[N:22]([CH3:37])[C:23]([C:26]5[CH:35]=[CH:34][CH:33]=[C:32]6[C:27]=5[CH:28]=[CH:29][C:30]([CH3:36])=[N:31]6)=[N:24][N:25]=4)[CH2:10][CH2:9][C:8]=3[CH:14]=2)[O:4][N:3]=1

Participants

3

Reactant 2

HCID 251050505-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 591505103-methyl-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine

Product 1

HCID 673585523-Methyl-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 3-methyl-6,7,8,9-tetrahydro-5H-isoxazolo[4,5-h][3]benzazepine (0.63 mmol) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline and was obtained as a faint yellow slightly hygroscopic solid (0.11 mmol).

Sources & evidence

ORD record
ord-4671e003ad9d4af99f801f99919fc599
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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