5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → HCID 67359279, compound

HRID 1668618Notes

Reaction equation

HRID 1668618 reaction equation
[CH3:1][S:2]([N:5]1[C:10]2=[CH:11][C:12]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14][C:13]=3[CH:19]=[C:9]2[O:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].[Cl:20][CH2:21][CH2:22][CH2:23][S:24][C:25]1[N:26]([CH3:41])[C:27]([C:30]2[CH:39]=[CH:38][CH:37]=[C:36]3[C:31]=2[CH:32]=[CH:33][C:34]([CH3:40])=[N:35]3)=[N:28][N:29]=1>>[ClH:20].[CH3:41][N:26]1[C:27]([C:30]2[CH:39]=[CH:38][CH:37]=[C:36]3[C:31]=2[CH:32]=[CH:33][C:34]([CH3:40])=[N:35]3)=[N:28][N:29]=[C:25]1[S:24][CH2:23][CH2:22][CH2:21][N:16]1[CH2:15][CH2:14][C:13]2[CH:19]=[C:9]3[O:8][CH2:7][CH2:6][N:5]([S:2]([CH3:1])(=[O:3])=[O:4])[C:10]3=[CH:11][C:12]=2[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 251050505-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 58495331HCID 58495331, compound

Product 1

HCID 67359279HCID 67359279, compound

Procedure

The title compound was prepared in analogy to General Procedure 1 from 4-(methylsulfonyl)-2,3,4,6,7,8,9,10-octahydro[1,4]oxazino[2,3-h][3]benzazepine (30 mg) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline and was obtained as a yellow slightly hygroscopic solid (20 mg).

Sources & evidence

ORD record
ord-916a634af93a4e958c65d2ca46d0b75e
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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