2-Methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine → 7-(3-{[5-(3,4-Difluorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio}propyl)-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668620Notes

Reaction equation

HRID 1668620 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:14]([N:15]=1)=[CH:13][C:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12][C:6]=1[CH:5]=2.[Cl:16][CH2:17][CH2:18][CH2:19][S:20][C:21]1[N:25]([CH3:26])[C:24]([C:27]2[CH:32]=[CH:31][C:30]([F:33])=[C:29]([F:34])[CH:28]=2)=[N:23][N:22]=1>>[ClH:16].[F:34][C:29]1[CH:28]=[C:27]([C:24]2[N:25]([CH3:26])[C:21]([S:20][CH2:19][CH2:18][CH2:17][N:10]3[CH2:9][CH2:8][C:7]4[CH:13]=[C:14]5[N:15]=[C:2]([CH3:1])[O:3][C:4]5=[CH:5][C:6]=4[CH2:12][CH2:11]3)=[N:22][N:23]=2)[CH:32]=[CH:31][C:30]=1[F:33]

Participants

3

Reactant 2

HCID 591504802-Methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepineHCID 594655693-[(3-Chloropropyl)thio]-5-(3,4-difluorophenyl)-4-methyl-4H-1,2,4-triazole

Product 1

HCID 673587207-(3-{[5-(3,4-Difluorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio}propyl)-2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.25 mmol) and 3-[(3-chloropropyl)thio]-5-(3,4-difluorophenyl)-4-methyl-4H-1,2,4-triazole and was obtained as a faint yellow slightly hygroscopic solid (0.11 mmol).

Sources & evidence

ORD record
ord-cf680e211efa4b51ac981d2966e16155
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

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