2-Methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine → 2-Methyl-7-(3-{[4-methyl-5-(tetrahydro-2H-pyran-4-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

HRID 1668621Notes

Reaction equation

HRID 1668621 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[C:14]([N:15]=1)=[CH:13][C:7]1[CH2:8][CH2:9][NH:10][CH2:11][CH2:12][C:6]=1[CH:5]=2.[Cl:16][CH2:17][CH2:18][CH2:19][S:20][C:21]1[N:25]([CH3:26])[C:24]([CH:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[N:23][N:22]=1>>[ClH:16].[CH3:1][C:2]1[O:3][C:4]2[C:14]([N:15]=1)=[CH:13][C:7]1[CH2:8][CH2:9][N:10]([CH2:17][CH2:18][CH2:19][S:20][C:21]3[N:25]([CH3:26])[C:24]([CH:27]4[CH2:28][CH2:29][O:30][CH2:31][CH2:32]4)=[N:23][N:22]=3)[CH2:11][CH2:12][C:6]=1[CH:5]=2

Participants

3

Reactant 2

HCID 591504802-Methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepineHCID 591504903-[(3-Chloropropyl)thio]-4-methyl-5-(tetrahydro-2H-pyran-4-yl)-4H-1,2,4-triazole

Product 1

HCID 673580372-Methyl-7-(3-{[4-methyl-5-(tetrahydro-2H-pyran-4-yl)-4H-1,2,4-triazol-3-yl]thio}propyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine hydrochloride

Procedure

The title compound was prepared in analogy to General Procedure 1 from 2-methyl-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (0.25 mmol) and 3-[(3-chloropropyl)thio]-4-methyl-5-(tetrahydro-2H-pyran-4-yl)-4H-1,2,4-triazole and was obtained as a faint yellow slightly hygroscopic solid (0.025 mmol).

Sources & evidence

ORD record
ord-6e2497a0ac894399af9c929ee542ac2b
Source dataset
uspto-grants-2011_08
Patent number
US07989444B2

Reaction notes

Loading…