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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1668629Generated: October 30, 2026

5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinoline → 2-ethyl-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-4,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine hydrochloride

https://huagongshe.com/reaction/1668629

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl)-2-methylquinolineHCID 25105050—
Reactant2-ethyl-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepineHCID 59150514—
Product2-ethyl-7-(3-{[4-methyl-5-(2-methyl-5-quinolinyl)-4H-1,2,4-triazol-3-yl]thio}propyl)-4,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine hydrochlorideHCID 67361167—

Reaction Steps

The title compound was prepared in analogy to General Procedure 1 from: 2-ethyl-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepine (0.43 mmol) and 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline (0.52 mmol) and was obtained as a colourless slightly hygroscopic solid (60 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07989444B2
Source datasetuspto-grants-2011_08
ORD IDord-66ebec4d6c4c4c7bae58166e60af8990
Source noteuspto-grants-2011_08