HRID1668641

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25105050

未命名化合物

HCID59150530

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc2c(-c3nnc(SCCCN4CCc5cc6nc(C(F)(F)F)oc6c(C)c5CC4)n3C)cccc2n1.Cl

HCID67359736

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to General Procedure 1 from 10-methyl-2-(trifluoromethyl)-6,7,8,9-tetrahydro-5H-[1,3]oxazolo[4,5-h][3]benzazepine (120 mg) was reacted with 5-{5-[(3-chloropropyl)thio]-4-methyl-4H-1,2,4-triazol-3-yl}-2-methylquinoline (212 mg) and was obtained as a colourless slightly hygroscopic solid (115 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9549aa4c782546a88456c08553090dd3
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07989444B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH3:1][C:2]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[CH:5]=[C:4]2[N:13]=[C:14]([C:16]([F:19])([F:18])[F:17])[O:15][C:3]=12.[Cl:20][CH2:21][CH2:22][CH2:23][S:24][C:25]1[N:26]([CH3:41])[C:27]([C:30]2[CH:39]=[CH:38][CH:37]=[C:36]3[C:31]=2[CH:32]=[CH:33][C:34]([CH3:40])=[N:35]3)=[N:28][N:29]=1>>[ClH:20].[CH3:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9]([CH2:21][CH2:22][CH2:23][S:24][C:25]3[N:26]([CH3:41])[C:27]([C:30]4[CH:39]=[CH:38][CH:37]=[C:36]5[C:31]=4[CH:32]=[CH:33][C:34]([CH3:40])=[N:35]5)=[N:28][N:29]=3)[CH2:8][CH2:7][C:6]=2[CH:5]=[C:4]2[N:13]=[C:14]([C:16]([F:19])([F:17])[F:18])[O:15][C:3]=12