Potassium Carbonate → HCID 86633451, compound

Participants

Reaction Steps

A solution of 4,6-dichloro-2-(6-methyl-pyridin-2-yl)-pyrimidine (Intermediate E) (1 eq, 0.417 mmol, 0.1 g) and C-(1H-indol-4-yl)-methylamine (1 eq, 0.417 mmol, 61 mg) and K2CO3 (1 eq, 0.417 mmol, 58 mg) in NMP (1 ml) is heated using microwave radiation at 120° C. for 1 hour. After cooling to room temperature, the mixture is partitioned between DCM/water and the organic portion is separated and concentrated in vacuo. The crude brown oil is purified by flash chromatography on silica eluting with 100% DCM and the appropriate fractions are combined and concentrated in vacuo. The resulting oil is dissolved in MeOH and loaded onto a SCX-2 cartridge eluting with MeOH followed by 2M NH3 in MeOH. The methanolic ammonia fractions are concentrated in vacuo and the residue is dissolved in DCM and concentrated in vacuo once again. The resulting solid is dried under vacuum to afford the title compound [M+H]+=350/352.

Provenance & Evidence