Ammonium Chloride → 6-Methylpicolinimidamide

HRID 1668662Notes

Reaction equation

HRID 1668662 reaction equation
CO[NH:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[N:7]=1)=[NH:5].[Cl-].[NH4+]>CCO.O>[CH3:12][C:8]1[N:7]=[C:6]([C:4]([NH2:5])=[NH:3])[CH:11]=[CH:10][CH:9]=1

Participants

5

Reactant 2

HCID 25517Ammonium ChlorideHCID 178502857HCID 178502857, compound

Product 1

HCID 142532006-Methylpicolinimidamide

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of N-Methoxy-6-methyl-pyridine-2-carboxamidine (1 eq, 32.9 mmol, 4.94 g) in EtOH (40 ml) and water (10 ml) at room temperature is added ammonium chloride (1 eq, 32.9 mmol, 1.76 g). The resulting mixture is heated to 80° C. for 4 hours and then allowed to cool to room temperature overnight. The solvent is removed in vacuo to afford the title compound which is used in subsequent steps without further purification. [2M+H]+=271

Workup

  1. temperatureto cool to room temperature overnight
  2. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-be35965576c14fd6877568b6087abf94
Source dataset
uspto-grants-2011_08
Patent number
US07989458B2

Reaction notes

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