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HRID1668667

反应详情

EQUATION

反应方程式

HRID 1668667 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CC(C)(C)OC(=O)N1CC[C@@H](CN)C1
HCID1514454

tert-Butyl (3S)-3-(aminomethyl)pyrrolidine-1-carboxylate

C10H20N2O2

结构：O=[N+]([O-])c1ccc(Cl)nc1NCc1c(Cl)cccc1Cl
HCID59705189

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CC[C@@H](CNc2ccc([N+](=O)[O-])c(NCc3c(Cl)cccc3Cl)n2)C1
HCID67341951

未命名化合物

收率 27.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A mixture of 16 (100 mg, 0.34 mmol), (S)-tert-Butyl-3-(aminomethyl)pyrrolidine-1-carboxylate (0.4 g, 2.0 mmol), potassium carbonate (56.4 mg, 0.41 mmol) in 10 mL MeCN was stirred at reflux for 2 hours. The solvent was removed by vacuum and the residue was purified by silica gel chromatography (MeOH:DCM=1:10) giving 17 [46 mg, 27% yield].

WORKUP

后处理

  1. temperatureat reflux for 2 hours
  2. customThe solvent was removed by vacuum
  3. customthe residue was purified by silica gel chromatography (MeOH:DCM=1:10)