HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57825048, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Acetonitrile ethyl acetate | HCID 21930812 | — |
| Reactant | 5-[1-(3-Bromo-phenyl)-vinyl]-2,3-dihydro-benzofuran | HCID 57825055 | — |
| Catalyst | HCID 178513473 | HCID 178513473 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57825048 | HCID 57825048 | 37% |
Reaction Steps
According to general method 2, a solution of iodine in ethyl acetate was added to a mixture of 5-[1-(3-bromo-phenyl)-vinyl]-2,3-dihydro-benzofuran (3.5 g, 11.6 mmol) and silver cyanate in ethyl acetate/acetonitrile. The crude product of this reaction was subsequently reacted with aqueous ammonia (30% by Vol). Purification by SCX column yielded 1.5 g of product (37%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989449B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-2fd7ea4589364a4e9b8547f64c6569ef |
| Source note | uspto-grants-2011_08 |