HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57825143, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Iodine | HCID 807 | — |
| Reactant | Acetonitrile ethyl acetate | HCID 21930812 | — |
| Reactant | HCID 57825247 | HCID 57825247 | — |
| Catalyst | HCID 178513473 | HCID 178513473 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57825143 | HCID 57825143 | — |
Reaction Steps
According to general method 2, a solution of iodine in ethyl acetate was added to a mixture of methanesulfonic acid 4-[1-(3-bromo-4-fluoro-phenyl)-vinyl]-2-methyl-phenyl ester (1400 mg, 3.6 mmol) and silver cyanate 1.1 eq in ethyl acetate/acetonitrile. The crude product of this reaction was subsequently reacted with aqueous ammonia (30% by vol). Purification by SCX followed by silica column (dichloromethane/methanol, 95:5) yield 650 mg of product (40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07989449B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-7c3db03aea7d412480c1213d363164fd |
| Source note | uspto-grants-2011_08 |