反应详情

In an analogous reaction sequence to that described for Building Block C, the reaction of 4-fluoro-3-methoxyacetophenone with 3-bromophenyllithium yielded the (RS)-1-(3-bromo-phenyl)-1-(4-fluoro-3-methoxy-phenyl)-ethanol which was used as crude material in the following elimination reaction with a catalytic amount of p-toluenesulfonic acid to yield the title compound (yield: 91% of theory) as a light yellow oil. TLC: Rf: 0.69 (silica gel; heptane:ethyl acetate=4:1, UV, 254 nm).