Ethanol → 3-Bromo-5-ethoxybenzoic acid

A solution of 3-bromo-5-ethoxy-benzonitrile (529 mg, 2.3 mmol) in a mixture of ethanol (8 mL) and water (1 mL) was treated with a solution of sodium hydroxide (47%, 0.66 mL) and the mixture heated under reflux for 1 hour. For the working-up, the mixture was evaporated under reduced pressure and the oily residue dissolved in tert-butylmethyl ether (60 mL) and water (30 mL). The organic layer was separated and evaporated, then treated again with tert-butylmethyl ether (120 mL) and 1 N hydrochloric acid (60 mL). The organic layer was separated and re-extracted twice with tert-butylmethyl ether (2×60 mL). The organic layers were combined, washed with brine, dried over sodium sulfate, and evaporated under reduced pressure. The title compound was obtained in quantitative yield and engaged in the next step without further purification. Mass (calculated) C9H9BrO3 [244]; (found) [M−H]+=243, 245.

1. temperaturethe mixture heated
2. temperatureunder reflux for 1 hour
3. customthe mixture was evaporated under reduced pressure
4. dissolutionthe oily residue dissolved in tert-butylmethyl ether (60 mL)
5. customThe organic layer was separated
6. customevaporated
7. additiontreated again with tert-butylmethyl ether (120 mL) and 1 N hydrochloric acid (60 mL)
8. customThe organic layer was separated
9. extractionre-extracted twice with tert-butylmethyl ether (2×60 mL)
10. washwashed with brine
11. dry with materialdried over sodium sulfate
12. customevaporated under reduced pressure

ORD record

ord-32f30f88ea33405fb4038f91929b08e9

Source dataset

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07989449B2