4-Bromo-1-methoxy-2-methylbenzene → HCID 57825209, compound

HRID 1668754Notes

Reaction equation

HRID 1668754 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])[CH:13]=1)[C:5](N(OC)C)=[O:6].Br[C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([CH3:29])[CH:22]=1>>[Br:1][C:2]1[CH:3]=[C:4]([C:5]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[C:23]([CH3:29])[CH:22]=2)=[O:6])[CH:11]=[C:12]([O:14][CH2:15][C:16]([F:17])([F:18])[F:19])[CH:13]=1

Participants

3

Reactant 2

HCID 6083154-Bromo-1-methoxy-2-methylbenzeneHCID 57825157HCID 57825157, compound

Product 1

HCID 57825209HCID 57825209, compoundYield 75%

Procedure

In analogy to the procedure described for the preparation of the Building Block AU, the reaction of the 3-bromo-N-methoxy-N-methyl-5-(2,2,2-trifluoro-ethoxy)-benzamide and 4-bromo-1-methoxy-2-methyl-benzene, beforehand transformed to the Grignard reagent, yielded the title compound as a white solid (yield: 75% of theory). Mass (calculated) C17H14BrF3O3 [402]; (found) [M]+=403, 405.

Workup

  1. customIn analogy to the procedure described for the preparation of the Building Block AU

Sources & evidence

ORD record
ord-dcf1f2e65cf345fd8831ce9a7cab06cf
Source dataset
uspto-grants-2011_08
Patent number
US07989449B2

Reaction notes

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