4-Bromo-1-methoxy-2-methylbenzene → (3-Bromo-5-cyclopropylmethoxy-phenyl)-(4-methoxy-3-methyl-phenyl)methanone

Participants

Reaction Steps

In analogy to the procedure described for the preparation of the Building Block AU, the reaction of the 3-bromo-5-cyclopropylmethoxy-N-methoxy-N-methyl-benzamide and 4-bromo-1-methoxy-2-methyl-benzene, beforehand transformed to the Grignard reagent, yielded the title compound as a colourless oil (yield: 76% of theory). Mass (calculated) C19H19BrO3 [374]; (found) [M+H]+=375, 377.

Provenance & Evidence