3,4-Dimethoxyaniline → HCID 42625918, compound

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Reaction Steps

The title compound was prepared from 4-chloro-2-methyl-quinazoline (178.6 mg, 1.0 mmol), 3,4-dimethoxy-aniline (153 mg, 1.0 mmol) and sodium acetate (98.4 mg, 1.2 mmol) similar to example 20 to give 295 mg (100%) of off white solids. 1H NMR (CDCl3): 7.85-7.70 (m, 4H), 7.51-7.46 (m, 1H), 7.38 (brs, 1H), 7.16 (dd, J=2.1 Hz, J=8.7 Hz, 1H), 6.90 (d, J=8.7 Hz, 1H), 3.95 (s, 3H)), 3.91 (s, 3H), 2.69 (s, 3H).

Provenance & Evidence